林榮辰 助理教授(LIN, JUNG-CHEN)

姓名：林榮辰
辦公室：牙醫館313
電話：02-2826-7314
電子信箱： linjungchen@nycu.edu.tw

學歷

2014/06 國立台灣大學醫學院免疫學研究所
博士 中華民國 台灣
2004/06 國立陽明交通大學牙醫學院口腔生物研究所
碩士 中華民國 台灣

研究方向

利用仿生生物材料來進行免疫工程和免疫調節

專長

免疫學、生物工程、免疫治療和疫苗學

經歷

2024/08 – 迄今        國立陽明交通大學牙醫學院 口腔組織工程暨生技材料研究所 專任助理教授
2022/02 – 2024/07 國立陽明交通大學牙醫學院 口腔生物研究所 兼任副教授
2016/02 – 2024/07 中央研究院生物醫學研究所 博士後研究學者
2015/02 – 2017/07 國防醫學院病理及寄生蟲研究所 兼任助理教授
2015/01 – 2016/01 國防醫學院病理及寄生蟲研究所 博士後研究員
2015/01 – 2015/12 匯德生物科技股份有限公司研發部 研發長
2014/09 – 2014/12 國立台灣大學醫學院免疫學研究所 博士後研究員

代表著作 (＃共同作者)

(1) Baghdasaryan, O.#, Khan, S.#, Lin, J.C.＃, Lee-Kin, J., Hsu, C.Y., Hu, C.M.J.* and Tan, C.* 2024. Synthetic control of living cells by intracellular polymerization. Trends Biotechnol. 42(2):241-252. (IF=17.3; 3/158; Q1)

(2) Chien, C.Y.＃, Lin, J.C.＃, Huang, C.Y., Hsu, C.Y., Yang, K.C., Chattopadhyay, S., Nikoloutsos, N, Hsieh, P.C., and Hu, C.M.J.* 2022. In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering. Adv Healthc Mater. e2201708. (IF=10; 8/96; Q1)

(3) Lin, J.C., Hsu, C.Y., Chen, J.Y., Fang, Z.S., Chen, H.W., Yao, B.Y., Shiau, G.H.M, Tsai, J.S., Gu, M., Jung, M.Y., Lee, T.Y., and Hu, C.M.J.* 2021. Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation. Adv Mater 33 (30):2101190. (IF=29.4; 5/178; Q1)

(4) Lin, J.C.＃, Chien, C.Y.＃, Lin, C.L.＃, Yao, B.Y., Chen, Y.I., Liu, Y.H., Fang, Z.S., Chen, J.Y., Chen, W.Y., Lee, N.N., Chen, H.W., and Hu, C.M.J.* 2019. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun 10(1):1057. (IF=16.6; 6/73; Q1)

榮譽成就

2023 第33屆王民寧獎:優秀論文獎—財團法人王民寧先生紀念基金會頒發
2023 傑出論文獎—第六屆國際再生醫學材料研討會暨台灣生物材料與控制釋放學會年會頒發
2022 111年度之博士後研究人員學術研究獎—科技部頒發
2014 研究生優秀著作獎—國立台灣大學醫學院頒發

專利

內部封定脂質體 (I653990, Taiwan) 2019/03/21
製備搭載胜肽之載體系統的方法 (PCT/US2020/043963) 2021/02/04
自然殺手細胞的放大方法 (I784426, Taiwan) 2022/11/21
人工抗原呈現細胞系統及其用途 (TW202208618A)

技術轉移

人工抗原呈現細胞系統及其用途 (震泰生醫) 2020/08/21

參與研究計畫

參與編輯者、實驗設計執行者、計畫撰寫（擔任博士後研究學者工作）
1.. 奈米主軸計畫 增幅mRNA疫苗免疫效性之奈米佐劑研發(2022-2024)
2. 自然科學及永續研究發展司 個人化奈米抗癌疫苗之製備與優化 (2019-2022)
3. 可裝載佐劑之奈米載體用於流感病毒疫苗的研發 (2016-2019)

著作 (＃共同作者)

(Present – 2019)
(1) Baghdasaryan, O.#, Khan, S.#, Lin, J.C.＃, Lee-Kin, J., Hsu, C.Y., Hu, C.M.J.* and Tan, C.* 2024. Synthetic control of living cells by intracellular polymerization. Trends Biotechnol 42(2):241-252. (IF=17.3; 3/158; Q1)

(2) Lin, C.L.; Fang, Z.S.; Hsu, C.Y.; Liu, Y.H.; Lin, J.C.; Yao, B.Y.; Li, F.A.; Yen, S.C.; Chang, Y.C., and Hu, C.M.J.* 2024. Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomater 173:325-335. (IF=9.7; 6/96; Q1)

(3) Chien, C.Y.＃, Lin, J.C.＃, Huang, C.Y., Hsu, C.Y., Yang, K.C., Chattopadhyay, S., Nikoloutsos, N, Hsieh, P.C., and Hu, C.M.J.* 2022. In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering. Adv Healthc Mater e2201708. (IF=10; 8/96; Q1)

(4) Yang, K.C., Lin, J.C., Tsai, H.H., Hsu, C.Y., Shih, V, and Hu, C.M.J.* 2021. Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Deliv Transl Res 11(4):1420-1437. (IF=5.4; 43/136; Q2)

(5) Lin, J.C., Hsu, C.Y., Chen, J.Y., Fang, Z.S., Chen, H.W., Yao, B.Y., Shiau, G.H.M, Tsai, J.S., Gu, M., Jung, M.Y., Lee, T.Y., and Hu, C.M.J.* 2021. Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation. Adv Mater 33 (30):2101190. (IF=29.4; 5/178; Q1)

(6) Chattopadhyay, S, Liu, Y.H., Fang, Z.S., Lin, C.L., Lin, J.C., Yao, B.Y., and Hu, C.M.J.* 2020. Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy. Nano Lett 20:2246-2256. (IF=10.8; 21/178; Q1)

(7) Lin, L.C.W., Huang, C.Y., Yao, B.Y., Lin, J.C., Agrawal, A., Algaissi, A., Peng, B.H., Liu, Y.H., Huang, P.H., Juang, R.H., Chang, Y.C., Tseng, C.T., Chen, H.W., and Hu, C.M.J.* 2019. Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus. Advanced Functional Materials 29(28):1807616. (IF=19; 8/178; Q1)

(8) Lin, J.C.＃, Chien, C.Y.＃, Lin, C.L.＃, Yao, B.Y., Chen, Y.I., Liu, Y.H., Fang, Z.S., Chen, J.Y., Chen, W.Y., Lee, N.N., Chen, H.W., and Hu, C.M.J.* 2019. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun 10(1):1057. (IF=16.6; 6/73; Q1)

(2018 – 2006)
(9) Lin, L.C., Chattopadhyay, S, Lin J.C., and Hu, C.M.J.* 2018. Advances and Opportunities in Nanoparticle- and Nanomaterial-Based Vaccines against Bacterial Infections. Adv Healthc Mater 7(13):e1701395. (IF=10; 8/96; Q1)

(10) Ka, S.M., Chao, L. K., Lin, J.C., Chen, S.T., Li, W.T., Lin, C.N., Cheng, J.C., Jheng, H.L., Chen A., and Hua, K.F.* 2016. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med 91:10-24. (IF=7.4 ;43/285; Q1)

(11) Chen, H.W., Huang, C.Y., Lin, S.Y., Fang, Z.S., Hsu, C.H., Lin, J.C., Chen, Y.I., Yao, B.Y., and Hu, C.M.J.* 2016. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials 106:111-8. (IF=14; 4/96; Q1)

(12) Ka, S.M., Lin, J.C., Lin, T.J., Liu, F.C., Chao, L.K., Ho, C.L., Yeh, L.T., Sytwu ,H.K., Hua, K.F., Chen, A.* 2015. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther 17:331. (IF=4.9; 12/34; Q2)

(13) Lin, J.C., Lin, S.C., Chen, W.Y., Yen, Y.T., Lai, C.W., Tao, M.H., Lin, Y.L., Miaw. S.C., and Wu-Hsieh, B.A.* 2014. Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development. J Immunol 193:1258-67. (IF=4.4; 77/161; Q2)

(14) Chang, L.Y., Lin, J.C., Chang, C.W., Ho, W.H., Chen, Y.T., Peng, J.L., and Hung, S.L.* 2009. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species, and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. J Periodontol 80:1330-7. (IF=4.3; 12/91; Q1)

(15) Chen, D.C., Lee, Y.Y., Yeh, P.Y., Lin, J.C., Chen, Y.L., and Hung, S.L.* 2008. Eugenol inhibited the antimicrobial functions of neutrophils. J Endod 34:176-80. (IF=4.2; 14/91; Q1)

(16) Lai, Y.L., Lin, J.C., Yang,S.F., Liu, T.Y., and Hung, S.L.* 2007. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodontal Res 42:69-76. (IF=3.5; 26/91; Q2)

(17) Shui, H.A., Ka, S.M., Lin, J.C., Lee, J.H., Jin, J.S., Lin ,Y.F., Sheu, L.F., and Chen, A.* 2006. Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model. Nephrol Dial Transplant 21:1794-802. (IF=6.1; 4/26; Q1)

研討會發表論文

1. Chung-Yao Hsu, Jung-Chen Lin (林榮辰), Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Aug). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023第六屆台灣國際再生醫學材料應用研討會 暨中華民國生醫材料及藥物制放年會.

2. Jung-Chen Lin (林榮辰), Chen-Ying Chien, Chi-Long Lin, Chung-Yao Hsu, Jui-Yi Chen, Bing-Yu Yao, Yu- Han Liu, Zih-Syun Fang, Hui-Wen Chen, Che-Ming J. Hu (2023, Aug). Gelated cells as a robust cell-mimicking biomaterial system for cancer immunotherapy and tissue engineering. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023第六屆台灣國際再生醫學材料應用研討會 暨中華民國生醫材料及藥物制放年會. 本人為第一作者.

3. Chung-Yao Hsu, Jung-Chen Lin (林榮辰), Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Jul). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes. 2023 台灣奈米生醫學會年會暨國際研討會.

4. Gwo Harn M Shiau, Jeng Fong Chiou, Long-Sheng Lu, Shian Ying Sung, Yin-Ju Chen, Jung-Chen Lin (林榮辰), Chung-Yao Hsu, Che-Ming J. Hu (2023, Jul). Unbiased T cell expansion by cancer taxidermy. 2023 台灣奈米生醫學會年會暨國際研討會.

5. Chung-Yao Hsu, Lung-Chen Lin (林榮辰) and Che-Ming Jack Hu (2022, Jul). Enabling antigen-specific T cell isolation via active cellular engagement with gelated cellular systems. 台灣奈米生醫學會學會年會暨國際研討會.

6. Chung-Yao Hsu, Lung-Chen Lin (林榮辰), Wei-Li Liao, Vicky Shih, Che-Ming Jack Hu (2020, Nov). Facile hydrogelation of dendritic cells for rigidity-dependent immune modulation. 臺灣奈米生醫學會年會暨研討會.

7. Jung-Chen Lin (林榮辰), Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Dec). Gelated dendritic cells as a robust artificial antigen presenting system for cancer immunotherapy . US-Japan Drug Delivery Symposium . 本人為第一作者.

8. Jung-Chen Lin (林榮辰), Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Mar). Preparation of Stable and Effective Artificial Antigen Presenting Cells by Intracellular Hydrogelation . 生醫年會. 本人為第一作者.

9. Jung-Chen Lin (林榮辰), Shih-Ching Lin, Wen-Yu Chen, Yu-Ting Yen Chin-Wen Lai, Mi-Hua Tao, Yi-Ling Lin, Shi-Chuen Miaw, Betty A. Wu-Hsieh (2015, May). Dengue Viral Protease Interaction with NF-κB Inhibitor α/β Results in Endothelial Cell Apoptosis and Hemorrhage Development. 第12屆財團法人台北市林榮耀教授學術教育基金會論文獎. 本人為第一作者.

教學活動

2021-present 基礎免疫學 國立陽明交通大學口腔生物研究所
2015-2020 發炎疾病:以病理學為本探索 國防醫學院病理及寄生蟲研究所
2015-2016 研究所課程 國防醫學院病理部

邀請演講

2024 Polymerizing intracellular cytosol for novel applications in cancer therapy and tissue
Engineering,國立陽明交通大學牙醫學院
2023 Gelated cells (GCs) as a robust cell-mimicking biomaterial system for biomedicine:
Present and future applications of GCs, 國防醫學院生物及解剖學研究所
2021 Instilling new life into cells with hydrogels: Present and future applications of gelated
cells (GCs) in biomedicine, 國立陽明交通大學牙醫學院
2019 Present and future applications of gelated cells (GCs) for biomedicine, 國防醫學院醫學
科學研究所